Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10-11 to 5.0 × 10-21). The sentinel blood pressure SNPs are enriched for association with DNA methylation at multiple nearby CpG sites, suggesting that, at some of the loci identified, DNA methylation may lie on the regulatory pathway linking sequence variation to blood pressure. The sentinel SNPs at the 12 new loci point to genes involved in vascular smooth muscle (IGFBP3, KCNK3, PDE3A and PRDM6) and renal (ARHGAP24, OSR1, SLC22A7 and TBX2) function. The new and known genetic variants predict increased left ventricular mass, circulating levels of NT-proBNP, and cardiovascular and all-cause mortality (P = 0.04 to 8.6 × 10-6). Our results provide new evidence for the role of DNA methylation in blood pressure regulation

The structure of the gut of a coral fish, Chelmon rostratus cuvier

Okajimas Folia Anatomica Japonica512-363-80OFAJ

Histochemical studies of mucus secreting cells in the gut of a coral fish, Chelmon rostratus cuvier

Okajimas Folia Anatomica Japonica512-381-90OFAJ

Ilmu kedokteran olahraga : pedoman untuk semua orang/ Giam

267 hal.; ill.; 24 cm

Papillary carcinoma arising in a thyroglossal cyst

Australian and New Zealand Journal of Surgery639738-740ANZJ

Ilmu kedokteran olahraga : pedoman untuk semua orang/ Giam

267 hal.; ill.; 24 cm

FPGA implementation of log-polar mapping

Log-polar or spatially variant image representation is an important component of active vision system in tracking process for many robotic applications due to its data compression ability, faster sampling rates and hence, direct to faster image-processing speed in machine vision system. In this paper, we try to implement log-polar mapping techniques on Xilinx FPGA (Field Programmable Gate Array) board for unwarping the omnidirectional images into panoramic images to present a wide angle of view by preserving fine output image quality in a higher data compression manner. Simulations are also run on MATLAB to find out the optimum mapping criterion. Some significant advantages of this new approach are: lighter processing system, lesser space utilisation, cost saving, faster processing speed and faster reset time (boot time) compared to a laptop computer that uses MATLAB for doing the unwarping process

Revealing the bearing capacity mechanisms of a penetrating spudcan through sand overlying clay

10.1680/geot.2008.58.10.793Geotechnique5810793-804GTNQ

A partially-observable markov decision process for dealing with dynamically changing environments

Part of the IFIP Advances in Information and Communication Technology book series (IFIPAICT, vol. 436).This paper offers a solution to the non-stationary POMDP problem, by making use of methods and concepts from the field of Bayesian non-parametrics, specifically dynamic hierarchical Dirichlet process priors. We combine block Gibbs sampling and importance sampling to perform inference. We evaluate the method in several benchmark policy learning task